Cryo-EM unravels the filamentous blueprint of the oocyte cytoplasmic lattice
A mouse oocyte cytoplasmic lattice (CPL) structure was resolved by cryo-EM, revealing a repeating filament composed of U-shaped baskets and adapter rings built from 14 protein subunits; PADI6 anchors the baskets, while SCMC dimers connect adjacent units, outlining how CPL assembles and supporting its crucial roles in oocyte maturation, early embryogenesis, and potential female reproductive disorders.