Tag

Polygenic

All articles tagged with #polygenic

science1 month ago•15 min saved

Genome-wide Scan Links 1,260 Variants to Personality Traits

A large genome-wide association study identified about 1,260 genetic variants associated with personality traits across the Big Five (extroversion, openness, conscientiousness, agreeableness, neuroticism), with roughly two-thirds newly found. The findings show personality is influenced by many genes each with small effects (a polygenic architecture), but genetics only partly explains variation and environmental factors also shape how traits express themselves.

via The New York Times|

#big-five #genetics #gwas

science1 month ago•6 min saved

Genome-wide scan uncovers ~1,260 variants linked to Big Five personality traits

A Nature-led study pooling data from 46 cohorts and more than 1 million people identified about 1,260 genetic variants linked to the Big Five personality traits (extraversion, agreeableness, conscientiousness, neuroticism, openness). While each variant has a tiny effect, collectively they explain roughly 5–16% of trait variation and appear more robust to family background than many other socio-behavioral traits. The team connected these variants to health and behavior, including smoking propensity (via conscientiousness), COVID-19 infection risk (via extraversion) and willingness to participate in research (via agreeableness and openness). The authors caution that genetics can help study personality, but it does not allow predicting an individual’s personality, and they find little evidence that shared family environment or assortative mating drives the associations.

via Nature|

#big-five #genetics #gwas

science5 months ago•18 min saved

The Complex Recipe of Personality: Genes Meet Life Experience

New genetic research shows personality is not fixed at birth. Twin studies once suggested substantial heritability, but genome-wide studies now estimate that only about 9–18% of personality variation is explained by common genetic variants, with the rest arising from environmental factors and gene–environment interactions. The idea of a simple “warrior gene” predictor has not held up, and personality appears to be polygenic and poly-environmental, influenced by many small effects across life experiences, including limited impact from major adulthood traumas but possible subtle effects from prenatal stress and foetal programming. Researchers emphasize very large, diverse datasets to uncover the tiny genetic contributions across the Big Five traits.

via BBC|

#genetics #heritability #personality