Single-Nucleus Atlas Maps Genetic Risk Across Brain Cell Types
A coordinated series of nine studies led by the PsychAD Consortium has produced a comprehensive, cell-type-resolved map of genetic risk for major brain disorders. By analyzing over 6 million nuclei from 1,494 donors, researchers identified thousands of gene-trait associations previously missed by bulk tissue analyses. The findings reveal that disorders like Alzheimer’s and schizophrenia share common molecular pathways but exhibit distinct cellular signatures, offering new targets for precision medicine.