Tag

Ras

All articles tagged with #ras

health1 month ago•4 min saved

Pancreatic cancer drug shows early promise against lung cancer

A small trial of daraxonrasib (Rasonque) in non-small-cell lung cancer with RAS mutations showed tumor shrinkage in more than 30% of participants, signaling potential beyond pancreatic cancer. A larger randomized trial is under way to confirm efficacy and durability, with regulatory decisions pending. The drug, which had already received FDA approval for pancreatic cancer after earlier successes, works as a molecular glue that exposes RAS to inhibition via cyclophilin A, a mechanism that could extend to other hard-to-treat tumors, though resistance can emerge.

via Nature|

#clinical-trial #daraxonrasib #health

health1 month ago•39 min saved

KRAS-targeting pancreatic cancer pill approved, signaling a broader oncology breakthrough

The FDA approved Revolution Medicines’ Rasonque, a daily KRAS-targeting pill for adults with metastatic pancreatic adenocarcinoma after one prior therapy or when chemotherapy isn’t feasible. In trials, median overall survival more than doubled (13.2 months vs 6.7) and death risk was reduced by about 60%, with no KRAS mutation test required. Priced at $39,800 per 30 days and backed by patient-support and expanded-access programs, the approval is viewed as a major advance and a potential platform for RAS-driven cancers, with off-label use anticipated and ongoing development of related therapies.

via Fortune|

#fda-approval #health #oncology

science4 months ago•7 min saved

Breakthrough drug targets ‘undruggable’ cancer, doubles survival in pancreatic cancer

A large trial shows the experimental drug daraxonrasib inhibits all three RAS family proteins and nearly doubles survival in advanced pancreatic cancer (13.2 months vs 6.7 with chemotherapy), marking a breakthrough against previously undruggable targets and highlighting prospects for combination therapies and broader use in hard-to-treat tumors.

via Nature|

#clinical-trial #daraxonrasib #pancreatic-cancer

sports5 months ago•7 min saved

RAS Metrics Put Packers’ Draft Class Under the Microscope

Kent Lee Platte’s Relative Athletic Score analysis finds the Packers’ 2026 draft class sitting 11th in overall RAS, led by elite marks like Dani Dennis-Sutton, while Chris McClellan’s weaker agility dampens the group; the piece includes Platte’s player-by-player notes, quotes from GM Brian Gutekunst, and context comparing this class to last year’s Packers’ RAS.

via Sports Illustrated|

#athletic-testing #green-bay-packers #kent-lee-platte

sports3 years ago•2 min saved

Understanding RAS: The Essential Draft Metric Explained

Relative Athletic Score (RAS) is a popular metric in the NFL draft that quantifies a player's athleticism compared to their position. It combines various categories measured at the NFL Combine and contextualizes them against other athletes of the same position. The metric was created by Kent Lee Platte, a lifelong Detroit Lions fan with a passion for math and metrics. The New York Jets had the highest average RAS in the 2023 NFL Draft, followed closely by the Indianapolis Colts and the New Orleans Saints. Ryan Poles, the Bears' football operations head, used RAS in his draft choices, with all ten of his picks registering over 8.0.

via NBC Sports|

#analytics #draft #football