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Sonogenetics

All articles tagged with #sonogenetics

technology2 months ago•23 min saved

MIT's Wearable Ultrasound Patch Paces the Heart Without Surgery

MIT researchers have created a chest-worn hydrogel patch that noninvasively paces the heart by enabling engineered heart cells to respond to ultrasound via a gene-therapy primer—a technique called sonogenetics. In tests on rats and pig hearts, the patch restored steady rhythms during daily activity, pointing toward a potential noninvasive alternative to implanted pacemakers and, with future closed‑loop sensing, a fully automated pacing system.

via ZME Science|

#gene-therapy #pacemaker #sonogenetics

technology2 months ago•23 min saved

Wearable ultrasound pacemaker uses engineered channels to noninvasively pace the heart

Ateam reports a wearable non-invasive ultrasound pacemaker (NUP) that activates engineered mechanosensitive channels (MscL-G22S) in cardiomyocytes to pace the heart. In vitro studies show synchronized calcium signaling; in vivo rat experiments demonstrate precise, non-invasive pacing (<1 mm) with controllable frequencies up to 9 Hz across heart chambers, restoring sinus rhythm in arrhythmia models. Long-term wearability and safety were evaluated in rats over 8 months, with translational potential shown in ex vivo porcine models. The system uses imaging-guided focused ultrasound and compact wearable hardware, offering a promising non-surgical alternative to traditional pacemakers, though human safety and clinical validation remain forthcoming.

via Nature|

#cardiomyocytes #non-invasive-pacemaker #sonogenetics

science4 months ago•10 min saved

Salk to Lead $41M ARPA-H Initiative to Make Ultrasound-Controlled Therapies a Reality

Salk Institute researcher Sreekanth Chalasani will lead a multi-institution ARPA-H program, funded up to $41.3 million over about 5.5 years, to advance sonogenetics—the use of ultrasound to control engineered cells—into a clinical therapy by building a protein toolkit, a wearable ultrasound delivery system, and preclinical data across partner sites toward trials, with potential applications such as peripheral neuropathies.

via Salk Institute for Biological Studies|

#arpa-h #peripheral-neuropathy #science