Tag

Sorla

All articles tagged with #sorla

SORLA protein could reverse Alzheimer’s damage, mouse study suggests
health6 hours ago

SORLA protein could reverse Alzheimer’s damage, mouse study suggests

A new study shows boosting levels of the brain protein SORLA can suppress tau tangles, reduce brain atrophy, and preserve synapses in mouse models of Alzheimer’s, suggesting a potential approach to reverse neurodegeneration. While promising, researchers caution that findings in mice need translation to humans, and current therapies mainly slow decline rather than reverse damage.

SORLA protein slows tau-driven brain damage in Alzheimer's model mice
science1 day ago

SORLA protein slows tau-driven brain damage in Alzheimer's model mice

Researchers show that upregulating the brain protein SORLA in tauopathy mice lowers tau tangles and brain atrophy, preserves synapses and plasticity, and reduces harmful gene activity in glial cells; SORLA deficiency worsens damage, suggesting SORLA as a therapeutic target and hinting that drugs targeting plexin-B receptors could be repurposed for tau-related dementias.