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Staphylococcus

All articles tagged with #staphylococcus

Oral-Gut Microbes Could Dampen Peanut Allergies
science1 month ago

Oral-Gut Microbes Could Dampen Peanut Allergies

Researchers identify mouth and gut bacteria, notably Rothia and Staphylococcus, that can break down peanut proteins Ara h 1 and Ara h 2. In children undergoing oral immunotherapy, higher levels of these microbes correlate with greater peanut tolerance and milder reactions; mouse studies show the same bacteria reduce anaphylactic responses. The findings hint at microbiome-based markers and therapies to manage peanut allergy, but human applications remain observational and require further testing.

Bacterial cGAS: Triggering Immunity with Viral RNA
science-and-technology2 years ago

Bacterial cGAS: Triggering Immunity with Viral RNA

Bacterial cyclic GMP-AMP synthase (cGAS) in the CBASS system senses viral RNA to initiate immunity in bacteria. Researchers investigated the activation mechanism of type I CBASS cyclases in staphylococci and found that a viral RNA, called cabRNA, activates the cyclase Ssc-CdnE03. The cabRNA contains secondary structures that are essential for cyclase activation. Mutations in positively charged residues of the cyclase disrupt the binding of cabRNA and impair cGAMP production. The study also revealed that other cyclases, such as Sha-CdnE01, from different CBASS systems can also be activated by cabRNA.