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Immunity

All articles tagged with #immunity

Self-experimentation with venom fuels a potential universal antivenom
environment2 days ago

Self-experimentation with venom fuels a potential universal antivenom

A Wisconsin window cleaner, Tim Friede, deliberately subjected himself to about 200 snake bites to build immunity, creating antibodies now used by Centivax to pursue a near-universal antivenom. His extraordinary risk—near-fatal collapses, coma, and severe tissue damage—has yielded antibodies that neutralize toxins from 19 elapid snakes, with a planned Australian pet trial before any human use. If successful, the work could reduce the roughly 138,000 annual snakebite deaths and 400,000 disfigurements, addressing a growing risk as climate change increases human–snake encounters.

via The Guardian|
#antivenom#centivax#climate-change
Dietary fats steer T cell ferroptosis to modulate immunity
science1 month ago

Dietary fats steer T cell ferroptosis to modulate immunity

Dietary lipid composition (PUFAs/MUFAs) determines mouse T cell resistance to ferroptosis, shaping T cell homeostasis and immune responses via lipid remodeling; these diet‑induced ferroptosis effects (DEFs) are microbiota‑independent and correlate with human plasma lipid profiles, with PUFA‑containing phospholipids driven by ACSL4 underpinning TFH cell development and broader T cell–mediated immunity, including anti‑tumor responses and CAR‑T therapy. The findings suggest targeting lipid metabolism could enhance vaccines and immunotherapies.

via Nature|
#acsl4#ferroptosis#immunity
Sneeze science: what your nose really tells you about health
health2 months ago

Sneeze science: what your nose really tells you about health

Sneeze science shows it’s a normal, protective reflex triggered by irritants and the trigeminal nerve, not a mystical omen. Causes include allergens, viruses, pollution, and even bright light; the visible blast travels under a metre at about 10 mph. Sneezing can spread infections such as cold, flu and Covid, so cover with a tissue or elbow and use a mask in high-risk settings; overall, sneezing is a routine physiological response influenced by environment and immunity, not a sign of danger.

via The Guardian|
#air-pollution#health#immunity
politics2 months ago

Judge poised to reject Trump’s bid to move hush-money case to federal court

A Manhattan federal judge signaled he is likely to deny Donald Trump’s bid to transfer his New York hush-money case to federal court after a 2nd Circuit panel ordered a fresh look; during a three-hour hearing, Judge Alvin K. Hellerstein pressed Trump’s lawyers on timing and strategy, characterizing the approach as navigating with two bites at the apple. The ruling may hinge on whether evidence relates to immunized official acts, and a decision is expected later, while the case remains in state court and the conviction stands.

via Politico|
#federal-court#hellerstein#hush-money
Environment-driven immune imprinting shields mice from allergy
science2 months ago

Environment-driven immune imprinting shields mice from allergy

A Nature study shows that environmentally rich exposures generate cross-reactive adaptive immune memory in mice, dampening allergic sensitization and anaphylaxis to related antigens. Protection can arise from type I memory or tolerogenic imprinting, is strongly influenced by timing (notably a perinatal window), and extends across diverse antigen spaces, including complex legume exposures—offering a mechanistic link between environment and the rise of allergic disease.

via Nature|
#allergy#cross-reactivity#environment
Shingles vaccine linked to slower aging markers in seniors
health2 months ago

Shingles vaccine linked to slower aging markers in seniors

A USC-led observational study using data from the Health and Retirement Study found that adults aged 70+ who received the shingles vaccine showed signs of slower biological aging, including reduced inflammation, slower epigenetic aging, and stronger immunity, with the strongest effects within three years post-vaccination; however, the cross-sectional design means causality can’t be established and further research is needed.

via CIDRAP|
#aging#epigenetic-aging#health
Supremacy Clause immunity could shield ICE agent in Renee Good shooting from Minnesota charges
politics2 months ago

Supremacy Clause immunity could shield ICE agent in Renee Good shooting from Minnesota charges

The article explains how the ICE agent who shot Renee Good could face Minnesota charges and how a potential immunity under the Supremacy Clause—contingent on acting within federal duties and in a reasonable, necessary manner—might bar state prosecution or push the case to federal court, with context on federal–state power and past precedents like Ruby Ridge.

via CBS News|
#ice#immunity#minnesota
Scientist Develops Beer-Based Vaccine for Poliovirus
science3 months ago

Scientist Develops Beer-Based Vaccine for Poliovirus

A virologist and home brewer, Chris Buck, claims to have created the world's first beer-based vaccine using genetically modified yeast, which he believes can immunize against certain viruses and potentially be used for other diseases like COVID-19 and flu. Despite concerns from the scientific community about safety and public trust, Buck has already brewed and tested his vaccine beer on himself, showing promising antibody responses, and aims to develop it further for broader use.

via The Times|
#beer-vaccine#home-brewing#immunity