All articles tagged with #streptomyces
Researchers identified a megacluster of biosynthetic genes in Streptomyces that encodes four antibiotics—stravidins, acidomycin, α-Me-KAPA, and dapamycins—plus the biotin‑targeting protein streptavidin, all aimed at blocking vitamin B7 (biotin) production at different steps, a multi‑pronged approach that could slow resistance and guide new antibiotic development.
Researchers discovered a potent new antibiotic, pre-methylenomycin C lactone, in a bacteria species studied for decades, which shows promise against resistant bacteria like MRSA and VRE, and remains effective after prolonged exposure, highlighting a new approach to antibiotic discovery by exploring biosynthetic intermediates.
Researchers have discovered umbrella-shaped toxic protein particles secreted by soil bacteria Streptomyces to inhibit the growth of competing species, particularly others of their own genus. These large complexes, unlike small-molecule antibiotics, are highly specific in targeting bacteria and have evaded discovery for over a century. The discovery, published in Nature, sheds light on the bacteria's combative strategies and potential clinical applications, including combating antibiotic-resistant bacteria such as those causing tuberculosis and diphtheria.