Tag

Antibiotic

All articles tagged with #antibiotic

science1 month ago•3 min saved

Soil-born antibiotic hits a novel ribosome site to tackle resistant bacteria

Researchers from the U.S., Canada, and Germany identify manikomycin, a naturally produced peptide antibiotic from the soil bacterium Streptomyces rimosus, that binds a previously untargeted site on bacterial ribosomes and kills difficult strains like Escherichia coli and Klebsiella pneumoniae; while promising due to its novel mode of action, it does not affect many Gram-positive bacteria and metabolizes quickly in the body, meaning it’s not yet a drug and will require optimization before clinical use.

via Gizmodo|

#antibiotic #antibiotic-resistance #manikomycin

science1 month ago•4 min saved

Manikomycin reveals a new weakness in drug-resistant bacteria by blocking ribosome exit

McMaster University researchers led by Gerry Wright discovered manikomycin, a novel antibiotic that blocks the ribosome exit site, effectively killing drug-resistant bacteria such as Salmonella, E. coli and Klebsiella and representing a new class of antibiotics; found by fractionating extracts of Streptomyces rimosus, it is non-toxic to human cells in early tests, with 60 derivatives developed and plans to optimize its activity and expand its spectrum.

via McMaster News|

#antibiotic #drugresistance #manikomycin

science5 months ago•5 min saved

Low-Dose Antibiotics Turn Gut Bacteria Into Longevity Boosters

Researchers found that small doses of cephaloridine prompt gut bacteria to produce colanic acid, extending lifespans in worms and improving cholesterol and insulin markers in mice, with the drug remaining in the gut to avoid systemic toxicity, suggesting a new microbe-focused approach to promoting longevity.

via ScienceDaily|

#aging #antibiotic #colanic-acid

health6 months ago•3 min saved

Innovative Super Antibiotic Targets Gut Infection While Preserving Microbiome

Researchers in Leiden have developed EVG7, a potent low-dose antibiotic that effectively targets C. difficile infections while preserving beneficial gut bacteria, reducing relapse risk and potentially limiting resistance, with human trials possible in a few years.

via SciTechDaily|

#antibiotic #c-difficile #evg7

science8 months ago•4 min saved

Hidden Antibiotic in Plain Sight Shows Promise Against Superbugs

Scientists discovered a new antibiotic compound, pre-methylenomycin C lactone, from soil bacteria that shows strong activity against drug-resistant bacteria like MRSA and E. faecium, without inducing resistance, offering promising potential for future antibiotic development.

via Live Science|

#antibiotic #drug-resistance #mrsa

science8 months ago•4 min saved

Scientists Discover Potent New Antibiotic Hidden in Plain Sight

Scientists have discovered a new, highly potent antibiotic called pre-methylenomycin C lactone within a well-studied bacterium, which is over 100 times more effective against resistant bacteria like MRSA and VRE, and shows no resistance development, offering a promising new approach to combat antimicrobial resistance.

via SciTechDaily|

#antibiotic #antimicrobial-resistance #drug-resistance

science8 months ago•2 min saved

New Soil Bacteria Antibiotic Shows Promise Against Superbugs

Scientists discovered a potent antibiotic compound, premethylenomycin C lactone, produced by soil bacteria that is 100 times more effective than the final product, offering a promising new approach to combat drug-resistant infections.

via Nature|

#antibiotic #drug-resistance #methylenomycin-a

science8 months ago•2 min saved

Scientists Discover Potent New Antibiotic Hidden in Nature

Researchers discovered a potent new antibiotic, pre-methylenomycin C lactone, in a bacteria species studied for decades, which shows promise against resistant bacteria like MRSA and VRE, and remains effective after prolonged exposure, highlighting a new approach to antibiotic discovery by exploring biosynthetic intermediates.

via ScienceAlert|

#antibiotic #antimicrobial #pre-methylenomycin

health8 months ago•2 min saved

New Antibiotic Discovered Hidden in Plain Sight

Researchers have discovered a powerful new antibiotic precursor, pre-methylenomycin C lactone, which shows over 100 times the effectiveness against certain bacteria and could be crucial in fighting antibiotic-resistant pathogens like MRSA and VRE. The molecule is a natural intermediate in the production of the well-known antibiotic methylenomycin A, and its stability and production potential make it a promising candidate for future drug development. This discovery also highlights a new approach to finding bioactive compounds by studying intermediate molecules in bacterial pathways.

via extremetech.com|

#antibiotic #bacteria #health

health8 months ago•2 min saved

New Antibiotic from Streptomyces Coelicolor Shows Promise Against Resistant Bacteria

Researchers discovered a new, potent antibiotic intermediate called pre-methylenomycin C lactone in the bacterium Streptomyces coelicolor, which is over 100 times more effective against resistant Gram-positive bacteria like MRSA and VRE, with no detected resistance development, offering promising potential in combating antimicrobial resistance.

via Genetic Engineering and Biotechnology News|

#amr #antibiotic #health

science8 months ago•3 min saved

Chemists Find Hidden Antibiotic for Drug-Resistant Bacteria

Chemists from Warwick and Monash Universities discovered a new, potent antibiotic, pre-methylenomycin C lactone, hiding as an intermediate in the natural biosynthesis of methylenomycin A. This compound shows over 100 times greater activity against Gram-positive bacteria, including resistant strains like MRSA and VRE, and may offer a new approach to combat antimicrobial resistance. The next steps involve pre-clinical testing and further development.

via Phys.org|

#amr #antibiotic #drug-resistant-bacteria

health9 months ago•5 min saved

AI-Driven Discovery of Targeted Antibiotics for Gut Bacteria and IBD Treatment

Researchers at McMaster University and MIT discovered a new narrow-spectrum antibiotic called enterololin that targets bacteria involved in IBD, using AI to predict its mechanism of action, significantly speeding up the drug development process and offering hope for better treatments for conditions like Crohn's disease.

via healthsci.mcmaster.ca|

#ai #antibiotic #drug-discovery

health10 months ago•4 min saved

Single Antibiotic Dose Effectively Treats Early Syphilis

A NIH-funded clinical trial found that a single dose of benzathine penicillin G is as effective as the traditional three-dose regimen for treating early syphilis, potentially simplifying treatment and improving patient compliance.

via National Institutes of Health (NIH) | (.gov)|

#antibiotic #clinical-trial #health

health1 year ago•3 min saved

Antibiotic Revealed to Lower Blood Pressure in Unexpected Role

Researchers discovered that ciprofloxacin, a common antibiotic, can bind to an allosteric site on the ACE enzyme, offering a new mechanism to potentially develop safer and more targeted blood pressure medications, opening new avenues for treating hypertension with fewer side effects.

via SciTechDaily|

#ace-enzyme #antibiotic #blood-pressure

health1 year ago•1 min saved

Roche's New Superbug Antibiotic Enters Final Testing Phase

Roche is advancing its experimental antibiotic zosurabalpin into Phase 3 clinical trials to combat drug-resistant acinetobacter baumannii, a bacteria causing serious hospital infections, using a novel mode of action to which bacteria have not yet developed resistance.

via Reuters|

#antibiotic #health #hospital-infections