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Tooth Regeneration

All articles tagged with #tooth regeneration

Could Humans Grow a Third Set of Teeth? Early Trial Hints at Possibility
science14 days ago

Could Humans Grow a Third Set of Teeth? Early Trial Hints at Possibility

A Japanese team is pursuing tooth regrowth by blocking USAG-1 to remove a brake on tooth formation. Toregem BioPharma’s TRG035 advanced to a first-in-human Phase I trial in 30 healthy men (ages 30–65) missing at least one molar to assess safety across five dose levels. While the approach has shown safety signals and raises the possibility of a third dentition, there is no proven tooth regrowth in people yet. The program targets congenital tooth agenesis and plans Phase II in Japan with potential U.S. development later, eyeing practical use around 2030.

via Yahoo|
#congenital-tooth-agenesis#science#tooth-development
Tooth Regrowth Nears Human Trials as Toregem Secures Funding
science1 month ago

Tooth Regrowth Nears Human Trials as Toregem Secures Funding

Toregem Biopharma has raised about $5.3 million to accelerate a drug-based approach that inhibits USAG-1, with plans for a Phase 2 trial in Japan to grow teeth from patients’ own tissue. Building on mouse studies and early human safety data, the company targets a potential market around 2030, but experts caution it may be limited to children due to available dental epithelial cells and could risk uncontrolled tooth growth elsewhere; whether it will work in humans remains uncertain.

via Futurism|
#clinical-trials#regenerative-dentistry#science
Two Stem-Cell Pathways Could Enable Real Tooth and Jawbone Regrowth
science2 months ago

Two Stem-Cell Pathways Could Enable Real Tooth and Jawbone Regrowth

Researchers identified two distinct mesenchymal stem cell lineages that drive tooth root and surrounding bone formation in developing teeth. One lineage from the apical papilla uses CXCL12 and Wnt signaling to become odontoblasts, cementoblasts, or osteoblasts; the other lineage in the dental follicle (PTHrP-expressing) forms alveolar bone via a Hedgehog–Foxf–signaling interaction that must be suppressed to activate bone fate. Mapping these pathways provides a mechanistic framework for tooth-root development and could inform stem-cell–based therapies to regenerate teeth and periodontal bone.

via SciTechDaily|
#alveolar-bone#hedgehog-foxf-axis#science
"Promising Drug Trial: Humans on the Verge of Regrowing Lost Teeth"
science3 years ago

"Promising Drug Trial: Humans on the Verge of Regrowing Lost Teeth"

A tooth-growing drug that stimulates tooth regeneration is set to enter clinical trials in July 2024. The drug targets tooth agenesis, a genetic condition causing the absence of teeth, and aims to enable tooth regrowth. Researchers discovered that blocking the interaction of the uterine sensitization-associated gene-1 (USAG-1) with other genes stimulates tooth growth in mice. If successful, this drug could revolutionize dental treatments and provide a solution for tooth loss and lack of tooth growth in humans. The goal is to make the treatment widely available by 2030.

via BGR|
#clinical-trials#dental-health#science