Aging brains suffer protein traffic jams that raise Alzheimer’s risk, Stanford study finds
Stanford researchers link aging-related brain decline to ‘protein traffic jams’: ribosomes stall during translation elongation, disrupting proteostasis and increasing misfolded protein aggregates tied to memory loss and Alzheimer's. Using the turquoise killifish as a fast-aging model, they show slowed or faulty protein production can decouple mRNA and protein levels, suggesting new targets—like boosting translation efficiency or ribosome quality control—to slow cognitive aging and neurodegenerative risk.