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Trna

All articles tagged with #trna

science9 days ago•8 min saved

Two genetic codes run in parallel, opening new frontiers in synthetic biology

Researchers led by George Church demonstrate a cell‑free system where two distinct genetic codes operate in parallel, using separate ribosome–tRNA pairs to translate the same mRNA into different proteins. This bypasses the need to rewrite an organism’s entire genome and could accelerate synthetic biology, though it hasn’t been tested in living cells and could cause unintended protein misfolding or cell death if attempted in vivo.

via Ars Technica|

#cell-free-translation #genetic-code #ribosome

molecular-and-structural-biology3 years ago•3 min saved

Unveiling the Structure of a Vital Protein Production Enzyme through Cryo-EM

Cryo-electron microscopy (cryo-EM) has revealed the three-dimensional structure of the tRNA splicing endonuclease (TSEN) enzyme, shedding light on its interaction with precursor tRNAs (pre-tRNAs) and the excision of introns. TSEN plays a crucial role in the correct conversion of tRNAs, and mutations that disrupt its interaction with the RNA kinase CLP1 can lead to neurodegenerative disorders. The study provides insights into the structural basis of substrate recognition by TSEN and may aid in the development of potential therapies for related genetic disorders.

via News-Medical.Net|

#cryo-em #enzyme #genetic-mutation

science3 years ago•18 min saved

"Creating Virus-Proof Bacteria with Swapped Genetic Code"

Scientists have created a swapped genetic code that prevents viral infections and gene transfer. The researchers swapped out one of the 64 codons in the genetic code of E. coli with a new codon that codes for a different amino acid. This change made it difficult for viruses to infect the bacteria and for genes to be transferred between bacteria. The study suggests that this approach could be used to create biocontainment systems for genetically modified organisms and to prevent viral contamination in biologic manufacturing.

via Nature.com|

#gene-transfer #genetic-code #science