Tag

Wnt Signaling

All articles tagged with #wnt signaling

science29 days ago•7 min saved

Two Stem-Cell Pathways Could Enable Real Tooth and Jawbone Regrowth

Researchers identified two distinct mesenchymal stem cell lineages that drive tooth root and surrounding bone formation in developing teeth. One lineage from the apical papilla uses CXCL12 and Wnt signaling to become odontoblasts, cementoblasts, or osteoblasts; the other lineage in the dental follicle (PTHrP-expressing) forms alveolar bone via a Hedgehog–Foxf–signaling interaction that must be suppressed to activate bone fate. Mapping these pathways provides a mechanistic framework for tooth-root development and could inform stem-cell–based therapies to regenerate teeth and periodontal bone.

via SciTechDaily|

#alveolar-bone #hedgehog-foxf-axis #science

science1 month ago•48 min saved

Caspase-5c amplifies Wnt signaling to sustain intestinal renewal

A Nature study identifies CASP5C, a human intestinal epithelial isoform of caspase-5, as a catalytic amplifier of Wnt signaling. CASP5C binds Dishevelled and cleaves APC at Asp556, destabilizing the β-catenin destruction complex and boosting Wnt activity to promote transit-amplifying cell proliferation and organoid growth; CASP5A and CASP5B lack this activity. CASP5C is upregulated during injury and in inflammatory bowel disease, revealing a non-immune role for inflammatory caspases in intestinal homeostasis.

via Nature|

#apc-cleavage #caspase-5 #intestinal-epithelium

science3 months ago•57 min saved

β-catenin mutational spectrum reveals tissue-tuned signaling across cancers

Researchers used saturation genome editing to test all 342 missense mutations in CTNNB1 exon 3, quantifying β-catenin signaling and revealing tissue-specific mutation patterns, a refined β-TRCP docking motif, and a spectrum of activating effects that correlate with hepatocellular carcinoma subtypes and tumor immune infiltration, aiding interpretation of CTNNB1 variants and guiding therapy.

via Nature|

#beta-catenin #cancer #ctnnb1

health10 months ago•4 min saved

Gut Cells 'Whisper' Like Brain Neurons, Redefining Self-Healing

Scientists discovered that support cells called telocytes in the gut use neuron-like extensions to deliver signals directly to stem cells, challenging previous assumptions and opening new avenues for treating gut diseases and improving regenerative therapies.

via Medical Xpress|

#cell-communication #gut-health #health