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RNA-targeting CRISPR revives immune visibility of prostate cancer

1 min read
Source: ScienceDaily
RNA-targeting CRISPR revives immune visibility of prostate cancer
Photo: ScienceDaily
TL;DR Summary

Researchers used an RNA-targeting CRISPR-Cas13 tool to lengthen the SPSB1 mRNA in prostate cancer cells, lowering SPSB1 protein levels and restoring the MHC-I immune signal. This made tumors more recognizable to T cells, enhancing immune checkpoint therapy in mice with no detectable off-target effects, and potentially extending to other immune-cold cancers.

Topics:health#crispr#health-and-medicine#immunotherapy#mhc-i#prostate-cancer#rna
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  1. CRISPR makes prostate cancer vulnerable to immunotherapy  ScienceDaily
  2. New Tool Supercharges Immunotherapy Against Prostate Cancer  SciTechDaily
  3. Scientists Found How Prostate Tumors Vanish from the Immune System's Radar and How to Make Them Visible Again  Medical Daily

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