Tag

Prostate Cancer

All articles tagged with #prostate cancer

science7 days ago•10 min saved

Prostate cancer hijacks amino acids to fuel cholesterol and therapy resistance

Weill Cornell researchers found that prostate tumors rewire amino acid metabolism to raise propionyl-CoA, which propionylates and stabilizes the SREBP2 transcription factor, keeping cholesterol production active even when hormone signaling is blocked. This supports androgen receptor activity and may drive resistance to therapies like enzalutamide; strategies that reduce isoleucine/valine intake or target the propionyl-CoA–SREBP2 axis could improve treatment responses.

via News-Medical|

#metabolism #propionyl-coa #prostate-cancer

health7 days ago•11 min saved

Prostate focal therapy: targeted treatment with hopeful early results but debated long-term proof

Focal therapy uses MRI-identified prostate lesions and energy-based methods (cryotherapy, laser ablation, and high-intensity focused ultrasound) to destroy cancer tissue in a single session, offering quicker recovery and fewer early side effects than surgery or radiation. While some centers report high satisfaction and favorable short- to mid-term outcomes, rigorous randomized trials are lacking and major guidelines label the approach experimental; uptake remains low and coverage by insurance is inconsistent, underscoring ongoing debates about long-term cancer control versus quality of life.

via STAT|

#focal-therapy #health #hifu

medical-research17 days ago•8 min saved

Ultra-low PSA target linked to better survival in metastatic prostate cancer

A real-world Veterans Health Administration study of 4,890 men with metastatic hormone-sensitive prostate cancer found that achieving a PSA below 0.2 ng/mL within 9 months of starting testosterone-deprivation therapy was associated with a 54% lower risk of death over a median follow-up of about 2 years. Notably, patients who only achieved a 90% PSA decline without hitting the 0.2 ng/mL threshold did not see a survival benefit. The findings suggest targeting PSA <0.2 ng/mL as a key treatment-success metric and indicate that more aggressive therapy may be warranted for those who do not reach this level; adding another drug to further block testosterone improved odds of reaching the threshold.

via News-Medical|

#androgen-deprivation-therapy #medical-research #metastatic

health18 days ago•56 min saved

Hunter Biden Offers Rare Update on Joe Biden’s Advanced Cancer Battle

In a BBC Newsnight interview, Hunter Biden reveals that Joe Biden's cancer—an aggressive prostate cancer diagnosed in May 2025—has progressed to stage 4 and metastasized to the bones, causing severe pain and debilitation, though his father is still fighting. Jill Biden has previously said the cancer has spread to his bones and that he may live with it.

via AOL.com|

#bone-metastasis #health #hunter-biden

politics20 days ago•2 min saved

Hunter Biden says Joe Biden's cancer has spread to his bones and is painful

Hunter Biden told BBC Newsnight that Joe Biden's prostate cancer has metastasized to his bones, causing significant pain. The 83-year-old former president was diagnosed in May 2025 and is undergoing ongoing treatment, including radiation and hormone therapy begun last October; Jill Biden said the disease requires constant monitoring. The family says Biden remains central to them, and Beau Biden’s 2015 brain cancer death is noted in context.

via USA Today|

#bbc-newsnight #bone-metastasis #hunter-biden

politics20 days ago•21 min saved

Hunter Biden says Joe Biden’s prostate cancer has metastasized and questions his pardon

Hunter Biden told BBC Newsnight that his father Joe Biden’s prostate cancer has spread and metastasized to the bones, describing the pain and sadness of watching him suffer, and he said the presidential pardon he received from his father was not fair or good for the country, also reflecting on his father’s health and policy decisions.

via The Washington Post|

#health #hunter-biden #joe-biden-politician

politics20 days ago•198 min saved

Hunter Biden says Joe Biden's cancer has metastasized and is painful

Hunter Biden told the BBC that Joe Biden's prostate cancer has spread to his bones, causing him pain and debilitation; the former president, who disclosed his cancer diagnosis in May 2025, remains active in public life and plans to publish a memoir after the midterm elections, while the family says it's been tough to watch.

via CNN|

#bbc-interview #hunter-biden #joe-biden

health21 days ago•6 min saved

Subtle Prostate Cancer Signs Highlight Need for Regular Screening

Prostate cancer is projected to be the most diagnosed cancer among U.S. men in 2026, and its early signs can be subtle or absent. Common symptoms include frequent urination (especially at night), difficulty starting urination, a burning sensation when urinating, blood in urine or semen, and erectile problems; two often-missed signs are a persistent feeling of incomplete bladder emptying and pelvic or lower back pain, which can indicate spread. Regular PSA screening is recommended—start at age 50 for average risk (40–45 for higher risk) and repeat every 2–3 years; persistent symptoms should prompt a urologist visit. Early detection offers more curative treatment options such as surgery or radiation.

via Raleigh News & Observer|

#early-symptoms #health #prostate-cancer

medical-research23 days ago•10 min saved

New combo strategy sharpens antibody-drug conjugates against advanced prostate cancer

UCLA researchers report that pairing DNA-damaging antibody-drug conjugates (ADCs) with BCL-XL inhibitors boosts cancer cell death and slows tumor growth in metastatic castration-resistant prostate cancer, shown in lab and mouse models. The work highlights co-targeting proteins B7-H3, PSMA, and STEAP1 to reach more cancer cells and notes that tumors with intact TP53 respond best, suggesting genetic testing could guide patient selection. The study provides a framework for next-generation, multi-payload, multi-target ADCs to improve durability of prostate cancer therapies, pending clinical trials.

via News-Medical|

#antibody-drug-conjugates #bcl-xl #medical-research

health23 days ago•15 min saved

MRI-before-biopsy could reshape prostate cancer screening, but uptake is uneven

Pre-biopsy MRI is transforming prostate cancer detection by guiding targeted biopsies and potentially reducing overdiagnosis and biopsy-related complications, but US adoption lags Europe and experts remain split on MRI-targeted biopsy alone versus combining it with systematic biopsies, due to training gaps, access disparities, and financial incentives.

via STAT|

#biopsy #health #mri

health-and-medicine1 month ago•7 min saved

RNA-targeting CRISPR revives immune visibility of prostate cancer

Researchers used an RNA-targeting CRISPR-Cas13 tool to lengthen the SPSB1 mRNA in prostate cancer cells, lowering SPSB1 protein levels and restoring the MHC-I immune signal. This made tumors more recognizable to T cells, enhancing immune checkpoint therapy in mice with no detectable off-target effects, and potentially extending to other immune-cold cancers.

via ScienceDaily|

#crispr #health-and-medicine #immunotherapy

health1 month ago•10 min saved

Early, targeted therapies reshape outcomes in metastatic prostate cancer

Advances in metastatic prostate cancer—earlier use of combination hormone therapy, targeted drugs, improved imaging with PSMA PET, and newer treatments like radioligand therapy and PARP inhibitors for eligible mutations—are extending survival. Biden’s case highlights how personalized, multidisciplinary care can manage the disease even when it has spread to bones and other organs. While outcomes vary by tumor biology and patient health, most men can live longer with fewer but meaningful side effects, though bone health and quality-of-life considerations remain important.

via CNN|

#health #hormone-therapy #metastatic-cancer

health-and-medicine1 month ago•5 min saved

Novel human antibody stalls spread of aggressive prostate cancer in preclinical study

Researchers at Umeå University and collaborators developed a fully human antibody that stopped growth and metastatic spread of an aggressive prostate cancer in preclinical tests, via a newly identified mechanism that may carry a lower risk of side effects. While promising, the therapy requires further safety studies and regulatory approval before clinical use, and researchers plan to explore its potential against other solid tumors.

via ScienceDaily|

#cancer-therapy #health-and-medicine #metastasis

health1 month ago•5 min saved

A PSA Test That Changed My Life: A Prostate Cancer Journey

A Winnipeg man recounts how a financial adviser’s push for a PSA test led to a cancer diagnosis, followed by surgery and potential radiation or hormone therapy; the piece highlights the issue of false positives, the emotional toll of waiting, and the importance of regular PSA screening for early detection.

via CBC|

#awareness #cancer-treatment #health

health1 month ago•6 min saved

Focal therapy for prostate cancer linked to fewer side effects, Clarkson among early adopters

Imperial College London researchers found minimally invasive focal therapy for localized prostate cancer offers cancer control comparable to radiotherapy or prostatectomy, with about a five-fold reduction in severe side effects like urinary incontinence, erectile dysfunction, and rectal issues. A decade on, only two of nearly 3,500 patients died from prostate cancer after focal therapy. The UK government is funding expansion of focal therapy, with about 15,000 annual cases eligible but only around 1,000 treated currently; Clarkson and Lord Cameron are among public figures who have used the treatment.

via The Independent|

#david-cameron #focal-therapy #health