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Prostate Cancer

All articles tagged with #prostate cancer

Early Balding Linked to Lower Prostate Cancer Risk
health1 day ago

Early Balding Linked to Lower Prostate Cancer Risk

A study of men aged 35–76 found that those who began balding by age 30 had a 29% lower risk of developing prostate cancer, and those who started balding even earlier had a 45% lower risk for both aggressive and less aggressive forms, possibly due to a shared genetic variant in the androgen receptor gene; however, prior research has yielded mixed results, with some studies linking baldness to higher risk of fatal prostate cancer. The exact mechanism remains unclear, and cancer screening guidance remains age-based (start at 40 for higher risk; general screening commonly begins at 55–69).

Tiny silica nanoparticles spark tumor death and boost immunotherapy in mouse prostate cancer
health-and-medicine5 days ago

Tiny silica nanoparticles spark tumor death and boost immunotherapy in mouse prostate cancer

Researchers engineered ultrasmall silica nanoparticles (Cornell Prime dots) that target prostate tumors, trigger ferroptosis (iron-driven cell death), and remodel the tumor immune environment to a more active state. In mouse models of aggressive prostate cancer, these particles alone modestly improved survival, but when combined with immune checkpoint therapy they produced complete or near-complete remissions and indefinite survival in 4 of 10 mice, rising to 5 of 10 with an added CSF-1R blockade. The treatment localized to tumors with no observed toxicity in healthy tissues. If safety and efficacy translate to humans, this approach could move toward clinical trials as a multi-pronged cancer therapy that enhances immunotherapy effectiveness.

Metformin and cancer: no broad benefit, only niche signals
health10 days ago

Metformin and cancer: no broad benefit, only niche signals

A review of recent evidence shows metformin does not provide broad cancer prevention or survival benefits. Large trials (MAST in low‑risk prostate cancer; STAMPEDE) and meta-analyses report no overall improvement in progression-free or overall survival, though some small studies hint at preventive effects in select high‑risk precancerous conditions. Observational links are likely biased, and metformin may even blunt exercise‑related longevity gains. The takeaway: metformin is not a universal cancer solution; any benefit is likely limited to poorly defined, narrow contexts that require rigorous, targeted trials.

PSA Alone Can Miss Prostate Cancer Growth; Regular Imaging Urged
medicine13 days ago

PSA Alone Can Miss Prostate Cancer Growth; Regular Imaging Urged

In two major trials of enzalutamide for advanced prostate cancer, up to about 25% of patients showed radiographic progression on imaging despite stable or undetectable PSA levels, correlating with worse survival. The findings suggest PSA monitoring alone may miss disease growth, underscoring the value of periodic imaging—especially in the first two years—and may prompt updates to clinical guidelines. Possible mechanisms include tumors evolving to grow independent of androgen receptor signaling through lineage plasticity or neuroendocrine transformation.

Estrogen Patches May Benefit Men With Prostate Cancer, NEJM Study Finds
health18 days ago

Estrogen Patches May Benefit Men With Prostate Cancer, NEJM Study Finds

A New England Journal of Medicine study found transdermal estradiol (estrogen patches) to be as effective as luteinizing hormone–releasing hormone antagonists in treating prostate cancer, with 3-year metastasis-free survival of 87.1% vs 85.9% and 5-year metastasis-free survival of 81.1% vs 79.2%. Estrogen patch users experienced far fewer hot flashes (44% vs 89%), but more breast enlargement (85% vs 42%). The report also notes a patch shortage for menopausal therapy and highlights potential broader benefits of estradiol, including brain health.

Low Testosterone May Mark Higher Cancer Risk, Large Study Finds
science18 days ago

Low Testosterone May Mark Higher Cancer Risk, Large Study Finds

An international analysis of 11 long-term studies including over 26,000 men found that very low testosterone levels are associated with a higher risk of cancer diagnosis and cancer death, particularly when testosterone falls below about 7.3–8.6 nmol/L; the study does not prove causation and does not advocate testosterone supplementation, but suggests testosterone could be a biomarker for overall health, with prostate cancer not showing a clear link in these data.

Clarkson Says Prostate Cancer Is In Remission After Ultrasound Therapy
entertainment23 days ago

Clarkson Says Prostate Cancer Is In Remission After Ultrasound Therapy

Jeremy Clarkson disclosed that his aggressive prostate cancer, diagnosed during Season 5 of Clarkson’s Farm, is in remission after ultrasound treatment. He described complications during therapy, including a catheter and a later incident involving blood-thinning medication, and urged men to get tested. He noted a recent prostate check found no cancer indicators and will continue regular blood tests to monitor his condition.

Jeremy Clarkson reveals remission after aggressive prostate cancer diagnosis
entertainment23 days ago

Jeremy Clarkson reveals remission after aggressive prostate cancer diagnosis

British TV presenter Jeremy Clarkson says he is in remission from an aggressive prostate cancer diagnosed in 2025, after follow-up tests showed no evidence of cancer. He credits early detection through regular testing, urges men to get screened, and notes he previously had part of his prostate removed and a heart procedure in 2024; he remains under regular monitoring with hopes of no recurrence.

Clarkson reveals aggressive prostate cancer and urges public to get checked
arts-entertainment23 days ago

Clarkson reveals aggressive prostate cancer and urges public to get checked

Jeremy Clarkson has disclosed an aggressive prostate cancer diagnosis, discovered early and now in remission after treatment. He has been meeting with David Cameron and other public figures to discuss their cancer experiences and has formed an informal support group. Clarkson urges everyone to get checked, stressing that PSA testing can save lives and that checking is not uncomfortable or undignified.

US Eyes Label Changes for Testosterone Therapy as New Safety Data Emerge
health24 days ago

US Eyes Label Changes for Testosterone Therapy as New Safety Data Emerge

US health officials are seeking label updates for testosterone replacement therapies after reviewing new safety data; although large studies found no meaningful rise in heart attacks or strokes among users, the proposed revisions would remove a blanket claim that safety and effectiveness aren’t established for age-related low testosterone and would update prostate cancer and enlarged-prostate warnings, with continued emphasis on proper diagnosis and ongoing monitoring; experts say the changes reflect evolving science and could improve access, but testosterone remains a medical therapy that should be prescribed only after thorough evaluation and not used indiscriminately; typical low testosterone is below about 300 ng/dL, though normal ranges vary by lab and guidelines.

Jeremy Clarkson Reveals Aggressive Prostate Cancer Detected Early, Underwent Surgery
entertainment27 days ago

Jeremy Clarkson Reveals Aggressive Prostate Cancer Detected Early, Underwent Surgery

Jeremy Clarkson announced on his Clarkson's Farm show that he has an aggressive prostate cancer detected early, with a biopsy confirming its aggressiveness; he has undergone surgery to remove the cancerous tissue and is hopeful for a full recovery, noting the cancer affected about 10% of his prostate and that this comes after his recent heart surgery, while urging men over 45 to get prostate checks.

Ultrasmall silica nanoparticles kill prostate tumors and boost antitumor immunity in mice
science27 days ago

Ultrasmall silica nanoparticles kill prostate tumors and boost antitumor immunity in mice

In preclinical mouse models, PSMA-targeted ultrasmall core-shell silica nanoparticles (Cornell Prime dots) directly induce ferroptotic death in aggressive prostate tumors and reprogram the tumor microenvironment from nonresponsive to highly active against cancer, while sparing healthy tissue. The particles also sensitize tumors to immunotherapies such as immune checkpoint blockade, with combination treatments yielding complete or near-complete remissions and extended survival in several mice, supporting further clinical investigation for this dual-action anti-cancer approach.