Senolytic drug duo triggers brain myelin loss in mice

A mouse study found the anti-aging drug combo dasatinib plus quercetin (D+Q) caused dramatic myelin loss in the brain, with younger mice more affected and the corpus callosum deteriorating. Damaged oligodendrocytes appeared to revert to a juvenile, less functional state resembling cells seen in multiple sclerosis, offering new MS clues while highlighting potential brain risks of senolytic therapies and cautioning off-label use.