Tag

Demyelination

All articles tagged with #demyelination

science1 month ago•92 min saved

Grey-matter microglia coordinate repair after focal white-matter demyelination

A targeted white‑matter lesion in a defined neural circuit triggers a transient grey‑matter microglial response, synapse loss, and reduced neuronal activity upstream of the lesion; these changes resolve as remyelination proceeds. Blocking microglia impairs remyelination, while aging diminishes this regenerative grey‑matter response, leading to chronic inflammation. The study reveals a circuit‑level regenerative plasticity that couples white‑matter integrity to grey‑matter function and suggests myelin‑regenerative therapies could mitigate chronic neuroinflammation in MS and related diseases.

via Nature|

#demyelination #microglia #myelin-regeneration

health3 years ago•5 min saved

Link Found Between Bacterial Toxin and Multiple Sclerosis

A specific toxin-producing gut bacteria, epsilon toxin-producing Clostridium perfringens, may be responsible for triggering the onset of multiple sclerosis (MS) and ongoing disease activity, according to a new study. The study identifies the bacteria in unusually high abundance within the gut microbiome of people with MS. Epsilon toxin opens the blood vessels of the brain allowing inflammatory cells to gain access to the central nervous system and cause demyelination characteristic of MS.

via Neuroscience News|

#central-nervous-system #demyelination #gut-bacteria