All articles tagged with #demyelination
A mouse study found the anti-aging drug combo dasatinib plus quercetin (D+Q) caused dramatic myelin loss in the brain, with younger mice more affected and the corpus callosum deteriorating. Damaged oligodendrocytes appeared to revert to a juvenile, less functional state resembling cells seen in multiple sclerosis, offering new MS clues while highlighting potential brain risks of senolytic therapies and cautioning off-label use.
A targeted white‑matter lesion in a defined neural circuit triggers a transient grey‑matter microglial response, synapse loss, and reduced neuronal activity upstream of the lesion; these changes resolve as remyelination proceeds. Blocking microglia impairs remyelination, while aging diminishes this regenerative grey‑matter response, leading to chronic inflammation. The study reveals a circuit‑level regenerative plasticity that couples white‑matter integrity to grey‑matter function and suggests myelin‑regenerative therapies could mitigate chronic neuroinflammation in MS and related diseases.
A specific toxin-producing gut bacteria, epsilon toxin-producing Clostridium perfringens, may be responsible for triggering the onset of multiple sclerosis (MS) and ongoing disease activity, according to a new study. The study identifies the bacteria in unusually high abundance within the gut microbiome of people with MS. Epsilon toxin opens the blood vessels of the brain allowing inflammatory cells to gain access to the central nervous system and cause demyelination characteristic of MS.