Vitamin B12–Derived Therapy Penetrates Brain Barrier to Target Glioblastoma
TL;DR
Researchers report that a vitamin B12–based compound, nitrosylcobalamin (NO-Cbl), can cross the blood-brain barrier, selectively accumulate in glioblastoma tumors, and deliver nitric oxide to cancer cells in preclinical models; it also shows synergistic activity with temozolomide (and TRAIL) to enhance tumor suppression, offering a promising but early approach that requires further validation before clinical use.
Topics:healthhealth-and-medicine#blood-brain-barrier#glioblastoma#health-and-medicine#nitric-oxide#nitrosylcobalamin#temozolomide
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