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Nitric Oxide

All articles tagged with #nitric oxide

Beet Juice May Lower Blood Pressure by Altering Mouth Bacteria
health1 month ago

Beet Juice May Lower Blood Pressure by Altering Mouth Bacteria

A two-week study found that daily nitrate-rich beet juice lowered blood pressure in older adults and altered the mouth’s bacteria—reducing Prevotella and increasing beneficial Neisseria—by enabling nitrate to nitric oxide conversion that relaxes blood vessels. The effect was not seen with a nitrate-free placebo, suggesting oral bacteria play a key role. Beets and other nitrate-rich vegetables may offer modest heart-health benefits when consumed regularly (about a cup daily), but they aren’t a replacement for blood pressure medications.

via Women's Health|
#beet-juice#blood-pressure#health
Vitamin B12–Derived Therapy Penetrates Brain Barrier to Target Glioblastoma
health-and-medicine3 months ago

Vitamin B12–Derived Therapy Penetrates Brain Barrier to Target Glioblastoma

Researchers report that a vitamin B12–based compound, nitrosylcobalamin (NO-Cbl), can cross the blood-brain barrier, selectively accumulate in glioblastoma tumors, and deliver nitric oxide to cancer cells in preclinical models; it also shows synergistic activity with temozolomide (and TRAIL) to enhance tumor suppression, offering a promising but early approach that requires further validation before clinical use.

via ScienceDaily|
#blood-brain-barrier#glioblastoma#health-and-medicine
Sugary gum after nitrate-rich veggies may boost heart benefits
health3 months ago

Sugary gum after nitrate-rich veggies may boost heart benefits

A study in the British Journal of Clinical Pharmacology found that chewing sugary gum for several hours after consuming nitrate-rich vegetables (like beets, spinach, and kale) increases mouth nitrite and systemic nitrite, which can temporarily lower blood pressure. The effect is short-lived and while it may aid endurance or post-meal BP, sugary gum carries dental health risks and isn’t a substitute for medical BP management.

via New York Post|
#blood-pressure#chewing-gum#health
Beetroot Juice Linked to Lower Blood Pressure in Seniors
health4 months ago

Beetroot Juice Linked to Lower Blood Pressure in Seniors

A University of Exeter study found older adults who drank nitrate-rich beetroot juice for two weeks experienced a drop in blood pressure, an effect not observed in younger participants, possibly due to age-related declines in nitric oxide production and changes in mouth bacteria that process nitrates. The findings suggest dietary nitrates from vegetables could support cardiovascular health but are not a substitute for medication, and larger trials are needed; other nitrate-rich foods like spinach and kale may offer similar benefits.

via NDTV|
#beetroot#blood-pressure#health
Watermelon May Boost Heart Health and Diet Quality
health-and-medicine4 months ago

Watermelon May Boost Heart Health and Diet Quality

New research finds watermelon consumption is associated with higher-quality diets and better nutrient intake, including more fiber, minerals, vitamins, and antioxidants, while lower in added sugars and saturated fat. A small clinical trial suggests watermelon juice may help preserve vascular function during hyperglycemia by supporting nitric oxide pathways via L-citrulline and L-arginine. Watermelon's high water content makes it hydrating and low in calories, and its lycopene content may further support cardiovascular health, but larger long-term studies are needed.

via ScienceDaily|
#diet-quality#health-and-medicine#heart-health
Mouthwash, Nitric Oxide, and Blood Pressure: A Nuanced Look at the Science
science5 months ago

Mouthwash, Nitric Oxide, and Blood Pressure: A Nuanced Look at the Science

Social media claims that mouthwash drastically raises blood pressure are not supported. Research shows that strong mouthwashes (eg, chlorhexidine) can disrupt oral bacteria and impede nitrate-to-nitrite conversion, potentially raising systolic blood pressure in some short-term trials. However, milder, everyday mouthwashes generally have little effect on this pathway or on heart health, and a long-term study found no link between regular mouthwash use and cardiovascular death. The takeaway is to choose a milder mouthwash, use it as directed, and maintain good oral hygiene, since untreated oral disease is linked to cardiovascular risk.

via ScienceAlert|
#blood-pressure#mouthwash#nitrate-nitrite-pathway
Blocking nitric oxide normalizes autism-like traits in mice
neuroscience7 months ago

Blocking nitric oxide normalizes autism-like traits in mice

Researchers show that high levels of brain nitric oxide cause S-nitrosylation and destruction of the TSC2 brake protein, hyperactivating the mTOR growth pathway and leading to autism-like behaviors in Shank3/Cntnap2 autism-model mice. Blocking nitric oxide preserves TSC2, slows the mTOR pathway, and restores typical brain function and social behaviors in these mice; conversely, activating mTOR in healthy mice induces autism-like traits. The mechanism appears in human SHANK3-mutant neurons and in blood samples from autistic children, suggesting a conserved NO–TSC2–mTOR axis and a potential drug target, though limitations include small human sample sizes and the need for broader studies.

via PsyPost|
#autism#mtor#neuroscience
Nitric Oxide Triggers TSC2 Loss, Overactivates mTOR in Autism
science7 months ago

Nitric Oxide Triggers TSC2 Loss, Overactivates mTOR in Autism

Excess nitric oxide can modify TSC2 via S-nitrosylation, marking it for destruction and removing the mTOR 'brake.' With TSC2 diminished, mTOR activity surges, disrupting neuronal signaling in autism models. Blocking NO signaling or engineering a NO-resistant TSC2 normalized mTOR and improved related cellular readouts in SHANK3 and CNTNAP2 mouse models, and clinical samples from children with SHANK3 mutations and idiopathic ASD showed reduced TSC2 and elevated mTOR, supporting a NO–TSC2–mTOR mechanism and suggesting nitric oxide inhibitors as a potential ASD therapy and biomarker target.

via Neuroscience News|
#autism#mtor#nitric-oxide
Blocking SCoR2 Could Halt Fat Production and Lower Cholesterol
science-health8 months ago

Blocking SCoR2 Could Halt Fat Production and Lower Cholesterol

A Cleveland team identified SCoR2, an enzyme that removes nitric oxide from proteins controlling fat storage and production. In mice, inhibiting SCoR2 prevented weight gain, reduced liver damage, and lowered cholesterol, suggesting a first‑in‑class drug could treat obesity and cardiovascular disease, with clinical trials anticipated in about 18 months.

via SciTechDaily|
#cholesterol#lipogenesis#nitric-oxide
Study Links Airborne Toxins to Autism Risk in High-Exposure Areas
health1 year ago

Study Links Airborne Toxins to Autism Risk in High-Exposure Areas

New research suggests that air pollution inhaled by pregnant women may increase the risk of autism in genetically predisposed children. The study, led by Dr. Haitham Amal, highlights the role of pollutants like nitric oxide in potentially causing inflammation and altering brain development. With autism rates rising, the research underscores the importance of understanding environmental factors contributing to the condition. The study reviewed various pollutants, including particulate matter and nitrogen oxides, and found a significant correlation between exposure and autism risk.

via Daily Mail|
#air-pollution#autism#brain-development
"Viagra's Potential Role in Preventing Alzheimer's Disease"
health2 years ago

"Viagra's Potential Role in Preventing Alzheimer's Disease"

Professor Rob Galloway explores the potential link between Viagra and dementia prevention, highlighting the importance of addressing underlying health issues rather than relying solely on medication for erectile dysfunction. Research suggests that Viagra may reduce dementia risk by increasing blood flow to the brain, but its side effects warrant caution. The study also prompts consideration of alternative methods to boost nitric oxide levels, such as consuming nitrate-rich foods and antioxidants, as well as engaging in regular physical activity to support brain health.

via Daily Mail|
#antioxidants#dementia#erectile-dysfunction