Aging Hits Two Milestone Shifts Around 44 and 60, Study Finds

A Nature Aging study of 108 adults analyzed 135,239 molecular features (RNA, proteins, lipids, microbiome) and found two abrupt aging shifts around ages 44 and 60, affecting metabolism and disease-related pathways across many molecules; these changes occur in both men and women and menopause isn’t the main driver. The authors caution the small sample size and call for broader, more granular follow-up research.