Blocking Brain Immune Cells Restores Sleep in Alzheimer’s-Model Mice

Researchers at the University of Kentucky found that sleep disruption in Alzheimer’s-model mice is driven by microglia-driven inflammation rather than amyloid plaques. When microglial activity was blocked, the mice gained about two extra hours of restorative sleep per night, although plaque levels did not change. This suggests that calming microglia could improve sleep and potentially slow disease progression, but the findings are currently limited to animal models.