Gaseous Molecule May Shield Brain Against Alzheimer's, Study in Mice Finds

A Johns Hopkins-led lab study in genetically modified mice showed that slowly releasing hydrogen sulfide (the gas behind fart smells) with NaGYY improved memory and motor function by about 50% after 12 weeks, suggesting hydrogen sulfide signaling might slow neurodegeneration and could inform future Alzheimer’s therapies. Results are preclinical and limited to animal models, though researchers are now exploring the molecular pathways, including interactions with GSK3β, to understand potential human applications.