Human cortex organoids partially take over a mouse brain, with mixed results
TL;DR
Stanford scientists replaced much of a mouse cortex with human brain organoid cells; grafts integrated in most animals and produced human cortical neurons with long-range connections, but lacked proper layering, yielding only intermediate behavioral and memory improvements—not yet a reliable human brain model; more work is needed to understand the cells’ roles.
- Researchers swap in human brain cells for a mouse’s cortex Ars Technica
- Developmental xenocortication using human-derived organoids in mice Nature
- Part-human part-mouse brain developed in science breakthrough BBC
- These Mice Have Partly Human Brains The New York Times
- Scientists create mice with part-human brains The Guardian
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