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In-Tumor Therapy Transforms Local Macrophages Into Cancer-Killing Agents

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Source: SciTechDaily
In-Tumor Therapy Transforms Local Macrophages Into Cancer-Killing Agents
Photo: SciTechDaily
TL;DR

KAIST researchers inject lipid nanoparticles carrying CAR mRNA and immunostimulants directly into tumors to reprogram resident tumor-associated macrophages into anticancer CAR-macrophages, boosting local and potentially systemic anti-tumor immunity and showing strong tumor suppression in animal models.

Topics:healthscience#car-macrophages#immunotherapy#in-situ-therapy#lipid-nanoparticles#science#tumor-microenvironment
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  1. Scientists Find Way to Turn Tumor-Protecting Cells Into Cancer Killers  SciTechDaily
  2. A targeted protein degrader that doubles as a cancer vaccine  C&EN
  3. Reprogramming cells within tumors with mRNA  RegMedNet
  4. New Chinese therapy uses immune memory to fight cancer  سانا
  5. Cancer Vaccine Forces Tumors To Reveal Themselves to the Immune System  Technology Networks

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