Living xenocortex model emerges as human brain tissue fills mouse cortex
TL;DR Summary
Stanford researchers transplanted lab-grown human cortical organoids into newborn mice engineered to lack most of their cortex; within three months the human tissue filled over 90% of cortical space, formed connections with the mouse brain and spinal cord, and acted as a living xenocortex. The model enables donor-specific studies of human brain development and disease (autism, epilepsy, schizophrenia, cerebral palsy), with observed von Economo neurons and potential for targeted drug testing, while ethical guardrails continue to be a focal discussion.
- Stanford scientists transplanted human brain tissue into mice missing most of their cortex; within months The Times of India
- Developmental xenocortication using human-derived organoids in mice nature.com
- These Mice Have Partly Human Brains The New York Times
- Stanford Medicine team creates advanced model for studying brain development, disorders Stanford Medicine
- Researchers have created a mouse with a partly human brain The Economist
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