Manikomycin reveals a new weakness in drug-resistant bacteria by blocking ribosome exit
TL;DR
McMaster University researchers led by Gerry Wright discovered manikomycin, a novel antibiotic that blocks the ribosome exit site, effectively killing drug-resistant bacteria such as Salmonella, E. coli and Klebsiella and representing a new class of antibiotics; found by fractionating extracts of Streptomyces rimosus, it is non-toxic to human cells in early tests, with 60 derivatives developed and plans to optimize its activity and expand its spectrum.
Topics:healthscience#antibiotic#drugresistance#manikomycin#note-extra-tag-trimmed#ribosomeexitsite#science#streptomycesrimosus
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