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Manikomycin reveals a new weakness in drug-resistant bacteria by blocking ribosome exit
science13 hours ago

Manikomycin reveals a new weakness in drug-resistant bacteria by blocking ribosome exit

McMaster University researchers led by Gerry Wright discovered manikomycin, a novel antibiotic that blocks the ribosome exit site, effectively killing drug-resistant bacteria such as Salmonella, E. coli and Klebsiella and representing a new class of antibiotics; found by fractionating extracts of Streptomyces rimosus, it is non-toxic to human cells in early tests, with 60 derivatives developed and plans to optimize its activity and expand its spectrum.

Panthers stun Wisconsin 83-82 on late layup in NCAA Tournament
sports2 months ago

Panthers stun Wisconsin 83-82 on late layup in NCAA Tournament

In the NCAA Tournament first round at Portland’s Moda Center, No. 12 seed High Point upset No. 5 Wisconsin 83-82 on Chase Johnston’s fast-break layup with 11.7 seconds left. Rob Martin led High Point with 23 points and 10 assists, while Wisconsin’s Nick Boyd scored 27 and John Blackwell added 22 points and 10 rebounds. High Point, coached by Flynn Clayman, advances to face the Hawaii/Arkansas winner in the Midwest second round.

India Charts a Global South Course in the AI Power Struggle
world3 months ago

India Charts a Global South Course in the AI Power Struggle

At the AI Impact Summit in New Delhi, India positions itself as a responsible, third-way partner for developing nations amid U.S.–China AI competition, arguing AI should be governed for public welfare and offering its large IT workforce and market as a testbed. Modi frames AI as a powerful technology that must be directed for good, while India pursues strategic autonomy, builds ties with middle powers, and signs the Pax Silica Declaration to protect supply chains, signaling a broader effort to shape AI governance and diplomacy for the Global South.