Tag

Drugresistance

All articles tagged with #drugresistance

science2 months ago•4 min saved

Manikomycin reveals a new weakness in drug-resistant bacteria by blocking ribosome exit

McMaster University researchers led by Gerry Wright discovered manikomycin, a novel antibiotic that blocks the ribosome exit site, effectively killing drug-resistant bacteria such as Salmonella, E. coli and Klebsiella and representing a new class of antibiotics; found by fractionating extracts of Streptomyces rimosus, it is non-toxic to human cells in early tests, with 60 derivatives developed and plans to optimize its activity and expand its spectrum.

via McMaster News|

#antibiotic #drugresistance #manikomycin

health-and-medicine2 years ago•3 min saved

"Combo Therapy Achieves Breakthrough in Babesiosis Elimination in Mice"

Researchers at Yale School of Medicine have discovered a new combination therapy that effectively eliminates drug-resistant babesiosis in mice, potentially offering immunity against future infections. The therapy combines the antimalarial drug tafenoquine with atovaquone, an anti-fungal/anti-parasite drug. This treatment cleared infections in both immunocompetent and immunocompromised mouse models and led to the development of protective immunity against the Babesia parasites. The findings could also contribute to the development of a babesiosis vaccine and offer insights into treatments for human malaria.

via LymeDisease.org|

##atovaquone #babesiosis

science-and-technology2 years ago•2 min saved

"AI-Driven Discovery Unveils Potent Antibiotics to Fight MRSA and Resistant Bacteria"

Scientists at MIT have discovered a new class of antibiotics, the first in over 60 years, using artificial intelligence to combat drug-resistant Staphylococcus aureus (MRSA). The team employed transparent deep learning models to predict the activity and toxicity of new compounds, leading to the identification of two promising antibiotic candidates. These findings, published in Nature, represent a significant advancement in the fight against antibiotic resistance and demonstrate the potential of AI in accelerating drug discovery.

via Euronews|

##ai #antibiotics