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Metformin targets gut mitochondria to boost glycemic control

1 min read
Source: Nature
Metformin targets gut mitochondria to boost glycemic control
Photo: Nature
TL;DR

New metabolomic and mouse studies show metformin lowers blood glucose by selectively inhibiting mitochondrial complex I in the intestinal epithelium, increasing intestinal glucose use and improving postprandial glycemic control, with raised levels of GDF15 and N-lactoyl-phenylalanine linked to systemic glucose regulation.

Topics:healthscience#glycemic-control#intestine#metformin#mitochondrial-complex-i#science#type-2-diabetes
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  1. Metformin lowers blood glucose by targeting intestinal mitochondrial complex I  Nature
  2. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control  Nature
  3. Metformin's real power may be in the gut  Medical Xpress
  4. Metformin Lowers Blood Sugar by Targeting Gut, Not Liver, Northwestern Study in Mice Finds  geneonline.com
  5. Metformin Targets Gut Mitochondria to Improve Glycemia  Bioengineer.org

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