Metformin targets gut mitochondria to boost glycemic control
TL;DR Summary
New metabolomic and mouse studies show metformin lowers blood glucose by selectively inhibiting mitochondrial complex I in the intestinal epithelium, increasing intestinal glucose use and improving postprandial glycemic control, with raised levels of GDF15 and N-lactoyl-phenylalanine linked to systemic glucose regulation.
- Metformin lowers blood glucose by targeting intestinal mitochondrial complex I Nature
- Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control Nature
- Metformin's real power may be in the gut Medical Xpress
- Metformin Lowers Blood Sugar by Targeting Gut, Not Liver, Northwestern Study in Mice Finds geneonline.com
- Metformin Targets Gut Mitochondria to Improve Glycemia Bioengineer.org
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