Natural Hormone FGF21 Rewires the Brain to Fight Obesity
TL;DR Summary
Researchers found that the hormone FGF21 acts in the hindbrain (nucleus of the solitary tract and area postrema) to regulate metabolism and reduce body weight, signaling a shared yet distinct pathway from GLP-1 drugs. The work, published in Cell Reports, suggests a specific brain circuit could be targeted for obesity and MASH therapies, though current FGF21 analogs can cause GI issues and bone loss, prompting hopes for safer, more precise treatments.
- Scientists Say This Natural Hormone Reverses Obesity by Targeting the Brain SciTechDaily
- Matthew Potthoff, Ph.D. (IMAGE) EurekAlert!
- Unlike GLP-1s, This Hormone Targets Metabolism Instead of Appetite Technology Networks
- FGF21 hormone targets hindbrain pathways to reverse obesity Drug Target Review
- Researchers identify mechanism for body weight-reducing hormone EurekAlert!
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