One Psilocybin Dose Triggers Lasting Brain Changes and Mood Boost

A study of 28 psilocybin-naive adults finds a single 25 mg dose can reconfigure brain activity and boost psychological well-being for up to a month. Researchers tracked brain changes with EEG, DTI, and fMRI, and found that higher brain entropy during the trip, along with greater psychological insights the next day, correlated with longer-term wellbeing improvements. The trial included a placebo session (1 mg) before the full dose, and participants could often tell which session contained the drug, which modestly limits the findings. The results help explain how psychedelic experiences may contribute to therapy, though some scientists caution that brain entropy is not a definitive biomarker and call for more sensitive measures.