All articles tagged with #tauopathy
Researchers show that upregulating the brain protein SORLA in tauopathy mice lowers tau tangles and brain atrophy, preserves synapses and plasticity, and reduces harmful gene activity in glial cells; SORLA deficiency worsens damage, suggesting SORLA as a therapeutic target and hinting that drugs targeting plexin-B receptors could be repurposed for tau-related dementias.
UCSD researchers used an AI-driven approach to identify chromogranin A as a molecular switch deciding whether Alzheimer’s pathology translates into memory loss. In tauopathy mice, removing CgA preserved learning and memory despite brain pathology, with females showing stronger protection. They also found catestatin, a peptide derived from CgA, which lowered disease markers and protected cognition across several mouse models. All findings are preclinical and require replication, dosing, safety studies, and regulatory review before any human testing, but the work aims to shift Alzheimer’s research toward prevention-based strategies.
New research suggests that breaking down excess glycogen in neurons can protect against dementia by reducing oxidative stress, with dietary restriction and drugs that activate glycogen phosphorylase showing potential as therapies for conditions like Alzheimer's.