Rare FNIP1 Mutations Link Fat Burning to Lower Cardiometabolic Risk
TL;DR Summary
A Nature study of over a million people found rare, protein-truncating FNIP1 mutations that lift a cellular energy brake, nudging the body to burn fat, improve fat distribution, and cut cardiometabolic disease risk by about 60%; lab and mouse experiments support the mechanism, suggesting FNIP1 as a potential drug target, though safety and efficacy of inhibiting FNIP1 are not yet proven.
- There's One Genetic Variant That Makes The Body Burn Fat Instead of Storing It ScienceAlert
- FNIP1 variants are associated with favourable metabolism in 1 million humans Nature
- People carrying a rare gene variant have naturally low body fat, healthier livers and better blood sugar levels Medical Xpress
- Scientists discover a ‘skinny gene’ mutation that acts like Ozempic Scientific American
- Geisinger's MyCode research helped identify target for treating obesity, cardiometabolic disease The Daily Item
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