HealTEC: Off-the-shelf non-living cells enable scalable, low-immunogenic therapies

Nature Biomedical Engineering reports HealTEC, an off-the-shelf, lyophilized non-living cell platform created by tannic‑acid–mediated inactivation and low‑temperature condensation of mesenchymal stem cells. HealTEC preserves immunomodulatory or angiogenic factors (or carries drug nanoparticles), enabling ready-to-use cell therapies for ulcerative colitis, hindlimb ischemia, and asthma, with long-term storage stability and markedly lower immunogenicity than living cells, supporting scalable manufacturing and commercialization.