CRISPR-edited hypoallergenic beagles offer a glimpse of allergy-free pets

Researchers used CRISPR to disable the gene that drives allergy-causing proteins in dog saliva and fur, creating two hypoallergenic beagles, Bailey and Alfie. Early tests showed no allergy protein in their saliva or hair, and a skin-prick test on a human volunteer suggested reduced reaction. While the method is a first for dogs, experts warn it will be years before any pet becomes available, and long-term safety, cost, and ethical implications—such as potentially dampening adoption of shelter animals—must be addressed before commercialization.