CRISPR Beagles: Allergy-Free Pups on the Horizon

Kindred Companion Sciences used CRISPR to knock out the Can f 1 allergen gene in beagles, producing Bailey and Alfie. Edited dogs showed no detectable Can f 1 in saliva or dander, and a skin-prick test on a volunteer who lived with Bailey produced no reaction (non-edited dog samples did). The team used a cloning-like method (somatic cell nuclear transfer) to create the embryos and plans to expand to other breeds and service dogs, though a public timeline and broader safety checks remain ongoing.