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22q112 Deletion Syndrome

All articles tagged with #22q112 deletion syndrome

science14 days ago•5 min saved

Early Glymphatic Dysfunction May Predict Psychosis Risk

Researchers tracking 85 people with 22q11.2 deletion syndrome over 25 years found that impaired brain waste clearance (glymphatic function) in childhood is linked to later psychosis. Those who developed psychotic symptoms showed weaker glymphatic development (lower ALPS index) and an excitatory/inhibitory imbalance, suggesting brain-cleaning failures early in life may contribute to psychosis and could offer avenues for preventive interventions.

via ScienceAlert|

#22q112-deletion-syndrome #alps-index #brain-development

science23 days ago•7 min saved

Sluggish Brain Drain in Childhood Signals Psychosis Risk in 22q11.2 Syndrome

A longitudinal study of children with 22q11.2 deletion shows that early impairment of the brain’s glymphatic waste-clearance system is linked to later psychotic symptoms, likely via hippocampal glutamate excess and reduced GABA inhibition; findings highlight a potential early biomarker and suggest interventions focused on sleep and inflammation to delay or prevent a first psychotic episode.

via Neuroscience News|

#22q112-deletion-syndrome #glutamate-gaba-balance #glymphatic-system

health-science2 years ago•4 min saved

"Uncovering the Origins of Psychosis: Insights from AI and Brain Networks"

A new study using brain scans and machine learning has identified two key brain regions, the anterior insula and ventral striatum, as crucial to psychosis in people with 22q11.2 deletion syndrome and those with psychosis of unknown causes. The findings support the theory that malfunctioning brain networks responsible for directing attention may lead to hallucinations and delusions. The study aims to pave the way for earlier diagnoses and better treatments for psychosis, potentially targeting these brain areas with existing treatments and studying the effects of antipsychotic medications.

via Livescience.com|

#22q112-deletion-syndrome #brain-scans #health-science

neuroscience2 years ago•9 min saved

"Uncovering Central Brain Systems in Psychosis: Insights from Neural Network Study"

Researchers have identified malfunctions in two critical brain systems—the "filter" and the "predictor"—in individuals with psychosis, shedding light on the underlying brain mechanisms. By studying young individuals with 22q11.2 deletion syndrome, the research offers insights into how these dysfunctions occur, potentially guiding future treatments and prevention strategies. The findings suggest that dysfunction of these brain systems makes it difficult to distinguish reality, leading to symptoms such as hallucinations and delusions. The study used advanced imaging and machine learning to confirm these dysfunctions, providing potential new targets for therapeutic interventions and offering implications for understanding and possibly preventing psychosis.

via Neuroscience News|

#22q112-deletion-syndrome #brain-systems #functional-mri