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Acetyl Coa

All articles tagged with #acetyl coa

science1 month ago•6 min saved

Mitochondrial Epigenetics Quiet Chronic Inflammation in Aging Cells

Mayo Clinic researchers link aging “zombie” cells’ persistent inflammation to a two‑part mechanism: damaged mitochondria leak immune-activating DNA/RNA to trigger inflammatory signals, and increased mitochondrial metabolism raises acetyl‑CoA, enabling epigenetic changes that make inflammatory genes more accessible. Blocking the mitochondrial citrate transporter SLC25A1 cuts acetyl‑CoA supply and dampens SASP-driven inflammation even with ongoing immune signaling, offering a way to reduce aging‑related inflammation without destroying the cells.

via SciTechDaily|

#acetyl-coa #epigenetics #mitochondria

science2 months ago•83 min saved

Mitochondrial citrate metabolism governs aging-related inflammation via epigenetic SASP control

A recent study finds that senescent cells rely on the mitochondrial citrate–acetyl‑CoA axis to maintain histone acetylation at SASP gene loci, supporting inflammatory output. Inhibiting citrate export (SLC25A1) or the mitochondrial pyruvate carrier reduces acetyl‑CoA supply, lowers SASP gene expression, and dampens inflammation without reversing senescence, which in aged mice translates to improved healthspan. The mtDNA–cGAS–STING inflammatory pathway and mitochondrial metabolic control function as independent but complementary inputs to SASP, revealing a mitochondrial–epigenetic checkpoint that could be targeted to mitigate aging-related inflammation.

via Nature|

#acetyl-coa #aging #histone-acetylation