Tag

Acot1

All articles tagged with #acot1

health-and-medicine1 month ago•6 min saved

Plant-derived compound slows rheumatoid arthritis in rats by rebalancing fatty acid metabolism

A plant-derived compound called obakulactone (OL) alleviates arthritis symptoms and joint damage in a rat model of RA by promoting ACOT1 degradation via the ubiquitin–proteasome pathway, correcting disrupted unsaturated fatty acid metabolism, and modulating immune cells and inflammatory signals. The study identifies ACOT1 as a potential drug target and suggests a new preclinical strategy for RA, though its safety and efficacy in humans remain to be tested.

via ScienceDaily|

#acot1 #fatty-acid-metabolism #health-and-medicine

health4 months ago•6 min saved

Plant-Derived Molecule Rebalances Fat Metabolism to Ease Rheumatoid Arthritis

Obakulactone (OL), a natural compound from Phellodendri cortex, promotes degradation of ACOT1 via the ubiquitin–proteasome system, restoring unsaturated fatty acid balance and reducing inflammation in a rat model of rheumatoid arthritis. The study reported OL lowered inflammatory cytokines and autoantibody markers, shifted macrophages toward anti-inflammatory states, and inhibited synovial fibroblast growth, with direct ACOT1 binding (Kd ~6 μM), suggesting a novel metabolic-targeted approach for RA treatment.

via SciTechDaily|

#acot1 #fatty-acid-metabolism #health