Tag

Fatty Acid Metabolism

All articles tagged with #fatty acid metabolism

health-and-medicine1 month ago•6 min saved

Plant-derived compound slows rheumatoid arthritis in rats by rebalancing fatty acid metabolism

A plant-derived compound called obakulactone (OL) alleviates arthritis symptoms and joint damage in a rat model of RA by promoting ACOT1 degradation via the ubiquitin–proteasome pathway, correcting disrupted unsaturated fatty acid metabolism, and modulating immune cells and inflammatory signals. The study identifies ACOT1 as a potential drug target and suggests a new preclinical strategy for RA, though its safety and efficacy in humans remain to be tested.

via ScienceDaily|

#acot1 #fatty-acid-metabolism #health-and-medicine

health4 months ago•6 min saved

Plant-Derived Molecule Rebalances Fat Metabolism to Ease Rheumatoid Arthritis

Obakulactone (OL), a natural compound from Phellodendri cortex, promotes degradation of ACOT1 via the ubiquitin–proteasome system, restoring unsaturated fatty acid balance and reducing inflammation in a rat model of rheumatoid arthritis. The study reported OL lowered inflammatory cytokines and autoantibody markers, shifted macrophages toward anti-inflammatory states, and inhibited synovial fibroblast growth, with direct ACOT1 binding (Kd ~6 μM), suggesting a novel metabolic-targeted approach for RA treatment.

via SciTechDaily|

#acot1 #fatty-acid-metabolism #health

health-and-medicine8 months ago•49 min saved

p53 Loss Promotes Breast Cancer Brain Metastasis via SCD1 and Fatty Acid Metabolism

The article discusses how inactivation of p53 promotes breast cancer metastasis to the brain by upregulating SCD1 and enhancing fatty acid metabolism, highlighting potential molecular targets for therapy.

via Nature|

#breast-cancer #fatty-acid-metabolism #health-and-medicine

health1 year ago•4 min saved

New Genes and Tools Enhance Breast Cancer Risk Assessment

A new study has identified 80 gene variants that may increase the risk of breast cancer, with 70 previously unknown. These variants were found in families with a high incidence of breast cancer but no known genetic causes. The study highlights the role of genes involved in fatty acid metabolism, suggesting that breast cancer cells may exploit these pathways for energy. The findings could lead to more inclusive genetic testing and targeted treatments. The research emphasizes the need for further lab experiments to confirm these predictions.

via Livescience.com|

#brca-genes #breast-cancer #fatty-acid-metabolism