Tag

Alphagenome

All articles tagged with #alphagenome

science1 month ago•6 min saved

DeepMind maps every possible DNA-letter mutation in the human genome

DeepMind releases the AlphaGenome Atlas, predicting the consequences of all 9 billion single-letter DNA mutations across the human genome with the AlphaGenome AI, including a single-score AVI to flag disease-causing changes; the atlas helps explore noncoding regions and DNA motifs, potentially aiding rare-disease diagnosis and biological insight, but does not replace experiments and clinical context. The data set (~1 petabyte) is freely available for non-commercial use via an API, lowering computational barriers and accelerating research.

via Nature|

#ai #alphagenome #deepmind

science8 months ago•6 min saved

DeepMind AI maps noncoding DNA to solve undiagnosed rare diseases

At the Undiagnosed Hackathon, DeepMind's AlphaGenome was used to predict how noncoding DNA mutations affect gene activity, helping researchers tie variants to 29 undiagnosed conditions and illustrating AI’s potential to illuminate the genome’s dark matter for hundreds of millions with undiagnosed rare diseases.

via Nature|

#ai #alphagenome #genomics

science8 months ago•3 min saved

DeepMind's AlphaGenome Lets AI Scan a Full Million-Letter Genome at Once

DeepMind's AlphaGenome, described in Nature, can analyze up to about 1 megabase of DNA at a time—roughly a million letters—outperforming prior AI models in 25 of 26 tests and predicting thousands of functional genomic tracks along with nearly 6,000 human genetic signals. Trained on both human and mouse genomes, it aims to illuminate how coding and non-coding regions interact and regulate genes. While praised as a milestone, experts caution that data quality and standardization remain limiting factors; the model could help diagnose rare genetic diseases, identify cancer mutations, and reveal drug targets, but it isn’t a complete solution yet.

via Gizmodo|

#alphagenome #artificial-intelligence #dna-sequencing

science8 months ago•2 min saved

DeepMind's AlphaGenome Maps How Mutations Drive Disease

Google DeepMind unveils AlphaGenome, an AI that predicts how genetic mutations affect gene regulation across tissues, helping scientists pinpoint disease-driving variants and potentially guide new therapies; trained on public human and mouse data, it analyzes large DNA segments to map essential regulatory elements and their cell-type effects, with early praise from researchers but noting that real-world validation remains ongoing.

via The Guardian|

#alphagenome #cancer #deepmind