Tag

Amines

All articles tagged with #amines

science1 month ago•23 min saved

Dichloromethane unlocks metal-free amide formation

Korean researchers report that dichloromethane (DCM) can act as an amide-coupling reagent, enabling amide bond formation between carboxylic acids and alkyl amines using a basic salt, without metal catalysts, and scalable to more than 20 g per batch. While the method often preserves stereochemistry, it struggles with bulky or aromatic amines, and DCM’s health hazards pose potential industrial hurdles. Nevertheless, the inexpensive, simple protocol could offer a practical alternative to harsher, toxic reagents in suitable cases.

via Chemical & Engineering News|

#amide-coupling #amines #carboxylic-acid

science2 months ago•5 min saved

Plastic waste could become a CO2 sponge through amine chemistry

Aarhus University researchers upcycled discarded polystyrene into a solid amine-based carbon-capture material that works at both smokestack CO2 concentrations and ambient air; a two‑step bromination (gold catalyst) and amination (copper catalyst) builds a tunable porous structure, showing potential to derive carbon-capture materials from waste plastics, though energy use and performance trade-offs remain.

via Ars Technica|

#amines #carbon-capture #plastic-waste

science1 year ago•1 min saved

Revolutionary Chemistry Discovery Promises Major Advances in Medicine and Agriculture

Scientists at the Technion have developed triazenolysis, a novel chemical process that converts alkenes into multifunctional amines, offering significant advancements in polymer, pharmaceutical, and agricultural production. Unlike the traditional ozonolysis, which forms carbon-oxygen bonds, triazenolysis efficiently creates carbon-nitrogen bonds, enhancing its applicability across various fields. This breakthrough, detailed in Nature Chemistry, was achieved by a team led by Prof. Mark Gandelman and supported by the Israel Science Foundation.

via SciTechDaily|

#amines #chemistry #innovation

science3 years ago•3 min saved

Cu-catalyzed N-alkylation of aliphatic amines with enantioconvergence.

Researchers have developed a new method for the enantioselective N-alkylation of aliphatic amines with α-carbonyl alkyl chlorides using chiral tridentate anionic ligands and copper catalysts. The method can convert feedstock chemicals, including ammonia and pharmaceutically-relevant amines, into unnatural chiral α-amino amides under mild and robust conditions with excellent enantioselectivity and functional group tolerance. The method has potential applications in the expedited synthesis of diverse amine drug molecules.

via Nature.com|

#amines #catalysis #chemistry