All articles tagged with #bioimaging
MIT researchers reveal a laser that self-organizes into a stable pencil beam inside a multimode fiber under precise on-axis high-power conditions, enabling ultrafast, high-resolution 3D imaging of the blood–brain barrier and real-time tracking of drug uptake without fluorescent tags—potentially speeding brain-targeted therapy research by about 25x and opening paths to imaging neurons and other tissues.
Researchers engineered magneto-sensitive fluorescent proteins (MagLOV) that show optically detected magnetic resonance in living cells at room temperature, with single-cell sensitivity and ~10% ODMR contrast. Through directed evolution, variants with tunable magnetic-field responses were created, supporting multiplexed readout, lock-in detection, and spatial localization of fluorescence using magnetic-field gradients (fluorescence MRI). MagLOV reports are also sensitive to the local spin environment (e.g., gadolinium), enabling in situ sensing of cellular microenvironments. Collectively, this work demonstrates a programmable, endogenously expressible quantum-sensing platform in biology with broad imaging and sensing applications.
Researchers at Kyushu University developed a novel organic molecule, CzTRZCN, that combines efficient light emission for displays and strong light absorption for deep-tissue bioimaging, overcoming conflicting molecular design requirements and paving the way for multifunctional materials in electronics and medical diagnostics.
Researchers from Trinity College Dublin and the Royal College of Surgeons in Ireland have developed innovative fluorescent dyes that change color to visualize different biological environments within cells, enabling real-time, high-contrast imaging of cellular processes. These dyes, capable of "switching on" and "off" based on their location within cellular structures, have potential applications in bio-sensing, drug delivery imaging, and the study of cellular dynamics, with implications for advancements in medicine and biology. The breakthrough, published in the journal Chem, was made possible through international collaboration and significant funding from Irish research bodies.