Tag

Chromatin Organization

All articles tagged with #chromatin organization

science8 months ago•138 min saved

Mapping the Human Genome in 3D and 4D

The article provides an extensive overview of the human 4D nucleome, detailing the genome's spatial organization, the methods used to map its 3D structure, and the relationship between genome architecture and function, including gene expression and nuclear localization, across different cell types and states.

via Nature|

#4d-nucleome #chromatin-organization #genome-structure

genetics3 years ago•9 min saved

RNAPII required for enhancer-promoter contact formation and loop extrusion antagonism.

A new study has found that the formation of enhancer-promoter contacts in chromatin organization requires RNA polymerase II (RNAPII) and antagonizes loop extrusion, a process that has been proposed to drive chromatin organization. The study also suggests that the Mediator-cohesin axis controls heterochromatin domain formation.

via Nature.com|

#chromatin-organization #cohesin #enhancer-promoter-contact