All articles tagged with #chromatin remodeling
A Science study shows the heart’s beating forces suppress tumor cell proliferation by altering gene expression through chromatin remodeling via Nesprin-2 and the LINC complex; mechanically unloaded hearts allow rapid tumor growth, pointing to potential therapies that mimic heart mechanics or target epigenetic pathways, though mechanisms and safety require further study.
Researchers show that upregulating the neural stem cell protein DMTF1 reverses aging-related proliferation decline in neural stem cells, restoring their growth in human and mouse models via chromatin remodeling and telomere-related pathways—offering a framework for brain repair therapies, though the work is early-stage.
The establishment of replication timing (RT) during early mammalian development has been a mystery. Using single-cell Repli-seq, researchers found that RT gradually emerges during preimplantation development in mice, with a progressive delineation of replication domains. The RT program becomes more defined from the 4-cell stage onwards, with a segregation between early and late RT values. Changes in histone modifications, such as H3K36me3 and H3K4me3, are associated with the consolidation of RT. The study provides insights into the epigenetic features and chromatin remodeling that occur during early embryonic development.