Tag

Cochlea

All articles tagged with #cochlea

science21 hours ago•17 min saved

Israeli study identifies rare cochlear cells with potential to reverse hearing loss

Tel Aviv University researchers report that inhibiting Notch signaling can trigger a rare subset of cochlear supporting cells (transdifferentiating Deiters’ cells) to become hair cells, offering a potential path to regenerate hearing. Using live imaging and single-cell multi-omics, the team shows this regenerative capacity exists in humans and could be leveraged with inner-ear injections, though it remains early basic research. Translation to patients will require overcoming regulatory, cost, and safety hurdles, but the work marks a significant step toward treatments that restore hearing rather than simply aiding it.

via The Jerusalem Post|

#cochlea #hair-cell-regeneration #hearing-loss

science1 day ago•6 min saved

Low-frequency hum decoded: ear’s backup cells drive infrasound sensation

A new study reveals that infrasound is detected via a novel inner-ear pathway: when hair cells can’t respond at very low frequencies, cochlear support cells generate electric fields that trigger nerve signals, causing a nonlinear jump in perceived loudness and helping explain why some people are more sensitive to low-frequency noise like heat pumps or wind turbines.

via Neuroscience News|

#cochlea #electrical-fields #hair-cells

health6 months ago•4 min saved

Revolutionary Ear Technology Paves the Way for Hearing Loss Solutions

Researchers at Rockefeller University have successfully kept a segment of the mammalian cochlea alive outside the body, enabling detailed study of its active sound amplification process. This breakthrough confirms that mammals rely on a universal biophysical principle involving Hopf bifurcation for amplifying faint sounds, paving the way for new treatments for sensorineural hearing loss by understanding and potentially repairing hair cell damage.

via Indian Defence Review|

#cochlea #ear-research #health

medical-science3 years ago•3 min saved

Revolutionary Discovery: A New Path to Cure Deafness

Researchers have discovered a new pathway into the inner ear, known as the cochlear aqueduct, which allows for the delivery of drugs directly to the cochlea. By utilizing the natural flow of fluids in the brain, scientists successfully restored hearing in deaf mice by delivering a gene therapy through this pathway. The findings suggest that cerebrospinal fluid transport could be a potential route for gene therapy to restore hearing in humans, offering hope for the millions of people worldwide who suffer from hearing loss.

via Study Finds|

#cochlea #deafness #drug-delivery

science3 years ago•4 min saved

New cell types and molecular features discovered in cochlea cell atlas through single-cell sequencing.

Researchers at the Pasteur Institute in France have created a comprehensive transcriptomic atlas of the mouse cochlea using single-cell sequencing, identifying nearly all cochlear cell types and discovering three previously unknown cell types. The study sheds light on the molecular basis of the tonotopic gradient of the basilar membrane's biophysical characteristics and reveals the expression of deafness genes in several cochlear cell types. The atlas will be useful for finding overlooked cochlear cells affected by particular deficits and may reveal causal sources for deafness of unknown origin.

via Phys.org|

#cochlea #deafness #gene-expression