Tag

Diabetic Kidney Disease

All articles tagged with #diabetic kidney disease

science29 days ago•84 min saved

B cell–driven Diabetic Kidney Disease uncovered by a high-resolution spatial atlas

Researchers built a cross-platform spatial atlas of diabetic kidney disease using CosMx and Xenium, integrated with snRNA-seq to define 11 tissue niches and injury microenvironments. They identify a B cell–predominant immune microenvironment that defines a DKD subset with faster kidney function decline, and develop tissue biomarkers plus a plasma protein panel that improve risk prediction beyond clinical models; findings validated in UK Biobank and supported by plasma proteomics, highlighting biomarker-guided B cell–targeted DKD trials.

via Nature|

#b-cells #biomarkers #diabetic-kidney-disease

health3 years ago•4 min saved

Statins and Diabetic Kidney Disease: A Risk Reduction Connection?

Statin initiation is associated with a reduced risk of diabetic kidney disease (DKD) and declining kidney function in patients with type 2 diabetes, according to a retrospective cohort study. The study's primary outcome was DKD, defined as a composite of kidney dysfunction and proteinuria sustained for at least 90 days. The researchers found that statin initiation was associated with lower risks of DKD and kidney function decline. However, other studies have reported the opposite, and physicians should monitor blood glucose levels more often upon initiation or escalations of statins.

via Medscape|

#blood-glucose #cardiovascular-disease #diabetic-kidney-disease