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Dopaminergic Neurons

All articles tagged with #dopaminergic neurons

science1 day ago•5 min saved

Virus Exposure Triggers Parkinson's-Like Brain Damage in Mice, Study Finds

A Texas A&M study used Theiler's murine encephalomyelitis virus (TMEV) in mice to model Parkinson's-like neurodegeneration. The virus infected dopamine-producing neurons and caused motor deficits that persisted after the virus was cleared, suggesting viruses could contribute to Parkinson's risk alongside genetic or environmental factors. This new viral model offers a tool to study disease progression and etiology, complementing genetic or toxin-based models, though TMEV itself does not infect humans.

via ScienceAlert|

#dopaminergic-neurons #mouse-model #neurodegeneration

health2 years ago•2 min saved

Advancements in Parkinson's cell therapies and treatment research

Scientists have developed a more efficient method for using stem cells to create dopaminergic neurons, the nerve cells responsible for producing dopamine. By genetically engineering the stem cells to remove four specific genes, researchers were able to increase the production of usable dopaminergic neurons from 25% to 69%. Transplants of neurons created using this new technique showed improved motor function in a rat model of Parkinson's disease. The researchers hope to transfer this method to clinical trials to improve cell therapies for Parkinson's patients.

via Parkinson's News Today|

#cell-therapy #dopaminergic-neurons #genetic-engineering

health2 years ago•3 min saved

Estrogen receptor beta activation holds potential for Parkinson's treatment

Treatment with cianidanol, a plant molecule that activates the estrogen receptor beta, has shown neuroprotective potential in cell and animal models of Parkinson's disease. Cianidanol reduced nerve cell death and lowered the expression of alpha-synuclein, a protein associated with Parkinson's. In a rat model, cianidanol improved motor function, balance, cognition, and led to a lesser loss of dopaminergic neurons. This study suggests that selectively activating the estrogen receptor beta could be a promising approach for Parkinson's treatment.

via Parkinson's News Today|

#cianidanol #dopaminergic-neurons #estrogen-receptor-beta