tldrdailynews.com logo
Tag

Cell Therapy

All articles tagged with #cell therapy

Lilly’s Kelonia Buyout Tightens the In Vivo CAR-T M&A Frontier
business1 month ago

Lilly’s Kelonia Buyout Tightens the In Vivo CAR-T M&A Frontier

Eli Lilly agreed to pay up to $7 billion for Kelonia Therapeutics, marking another high-profile in vivo CAR-T deal as Big Pharma bets on the space; analysts say deal activity may slow due to a shrinking pool of viable targets, with Umoja Biopharma identified as a prime remaining buyout candidate and offshore players like Starna Therapeutics likely to surface. The pace will hinge on Kelonia’s data and whether the platform can extend beyond oncology into autoimmune indications.

via Fierce Biotech|
#biotech-manda#business#cell-therapy
Cloaked mitochondria extend survival in mouse model of mitochondrial disease
science2 months ago

Cloaked mitochondria extend survival in mouse model of mitochondrial disease

Researchers wrapped mitochondria in red blood cell membranes to shield them from destruction and facilitate cellular entry. In a Leigh syndrome mouse model, this capsule-like delivery increased survival by about two weeks (roughly 20%), with ~80% of cells taking up the mitochondria—significantly higher than naked mitochondria. The approach preserves the mitochondria’s membrane potential, marking a major efficiency advance, though some scientists caution that claims such as preventing Parkinson’s disease in mice may be overstated.

via Nature|
#cell-therapy#leigh-syndrome#mitochondrial-transplantation
J&J Bets Big on U.S. Cell-Therapy Manufacturing with $1B Pennsylvania Facility
business3 months ago

J&J Bets Big on U.S. Cell-Therapy Manufacturing with $1B Pennsylvania Facility

Johnson & Johnson announced more than a $1 billion investment to build a next-generation cell-therapy manufacturing facility in Lower Gwynedd, Montgomery County, Pennsylvania, expanding U.S. manufacturing capacity, creating 500+ biomanufacturing jobs and up to 4,000 construction roles, as part of a broader $55 billion U.S. investment through 2029 to advance cancer, immune-mediated, and neurological therapies.

via Johnson & Johnson|
#biomanufacturing#business#cell-therapy
Bristol Myers Squibb Expands Cell Therapy Portfolio with Orbital Therapeutics Acquisition
business7 months ago

Bristol Myers Squibb Expands Cell Therapy Portfolio with Orbital Therapeutics Acquisition

Bristol Myers Squibb is acquiring Orbital Therapeutics for $1.5 billion to enhance its cell therapy portfolio with next-generation RNA medicines, including the investigational CAR T-cell therapy OTX-201, aimed at autoimmune diseases, leveraging Orbital's innovative RNA platform for more accessible and effective treatments.

via Bristol Myers Squibb|
#acquisition#bristol-myers-squibb#business
Breakthrough in Diabetes Treatment: CRISPR and Bioengineering Enable Immune-Evasive Insulin-Producing Cells
health8 months ago

Breakthrough in Diabetes Treatment: CRISPR and Bioengineering Enable Immune-Evasive Insulin-Producing Cells

Researchers have successfully implanted CRISPR-edited pancreatic cells into a person with type 1 diabetes, enabling the cells to produce insulin and evade immune detection without immunosuppressive drugs, marking a significant step toward a potential cure for the disease. However, the study involved only one patient and more research is needed to confirm efficacy.

via Nature|
#cell-therapy#crispr#diabetes
FDA Officials Push for Faster Approvals in Cell, Gene, and Rare Disease Therapies
health-and-science11 months ago

FDA Officials Push for Faster Approvals in Cell, Gene, and Rare Disease Therapies

At a June 5 FDA roundtable, officials and experts discussed streamlining regulations to accelerate the development of cell and gene therapies, with suggestions including adopting China's two-tier system and reducing bureaucratic delays, amid concerns over international competition and innovative breakthroughs like CRISPR treatments for rare diseases.

via Fierce Biotech|
#biotech#cell-therapy#fda
"CAR T-Cell Therapy Shows Promise as One-Shot Asthma Cure in Mice"
health2 years ago

"CAR T-Cell Therapy Shows Promise as One-Shot Asthma Cure in Mice"

Chinese scientists have developed a pioneering CAR-T cell therapy that offers the potential for a one-time treatment for asthma, a condition that currently requires lifelong management. This therapy, which targets key cytokines driving asthma, has shown promising results in animal studies, providing long-term relief from symptoms. While the findings are encouraging, experts stress the need for further research to ensure the therapy's safety and efficacy in humans.

via Interesting Engineering|
#asthma#car-t#cell-therapy
Chinese Scientists Announce Breakthrough Diabetes Cure with Stem Cell Therapy
health2 years ago

Chinese Scientists Announce Breakthrough Diabetes Cure with Stem Cell Therapy

Chinese scientists have reported a potential cure for diabetes using innovative cell therapy, successfully treating a 59-year-old man with type 2 diabetes who became insulin-independent within eleven weeks of a cell transplant. The patient has remained medication-free for over 33 months, marking a significant breakthrough, though further large-scale trials are needed to confirm the treatment's efficacy and safety.

via NDTV|
#cell-therapy#china#diabetes
"China Achieves World's First Diabetes Cure with Cell Therapy"
health2 years ago

"China Achieves World's First Diabetes Cure with Cell Therapy"

Chinese scientists have reportedly cured a 59-year-old man of type 2 diabetes using cell therapy, marking a groundbreaking achievement in regenerative medicine. The patient, who had severe complications and was dependent on insulin, no longer requires external insulin or oral medication after the cell transplant. This breakthrough could significantly impact diabetes treatment, especially in China, which has the highest number of diabetes patients globally. Further studies are needed to confirm these findings in a larger patient population.

via Interesting Engineering|
#cell-therapy#china#diabetes